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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年第13卷第3期页码 354-364 doi: 10.1007/s11684-018-0665-5

摘要： The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- ) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cell transplantation (allo-HSCT). High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology and were MRD-positive after allo-HSCT were studied ( =47). The MRD-positive status was considered if leukemia-associated aberrant immune phenotypes or Wilms’ tumor gene 1 expression is present in a single bone marrow sample. The cumulative incidence of the relapse and non-relapse mortality 2 years after immunotherapy were 14.5% and 21.4% ( =0.377) and 9.1% and 0.0% ( =0.985) for patients in the IFN- and chemo-DLI groups, respectively. The probability of disease-free and overall survival 2 years after immunotherapy were 76.4% and 78.6% ( =0.891) and 84.3% and 84.6% ( =0.972) for patients in the IFN- and chemo-DLI groups, respectively. Persistent MRD after immunotherapy was associated with poor survival. Thus, the MRD-directed immunotherapy was effective for patients with high-risk MDS who were MRD-positive after allo-HSCT, and the efficacy was comparable between chemo-DLI and IFN- treatment.

关键词： donor leukocyte infusion hematopoietic stem cell transplantation interferon-

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High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

《化学科学与工程前沿（英文）》 2007年第1卷第4期页码 399-403 doi: 10.1007/s11705-007-0073-x

摘要： The present work focused on the high expression of recombinant human consensus interferon- (cIFN) by Pichia pastoris. The cycle of glycerol feeding, the strategy of methanol feeding and the optimum pH for protein induction were studied. The optimized strategies were a 4-h glycerol-feeding period, induction pH being kept at 5.0 and methanol concentration being kept under 5 g/L. The maximum dry cell weight, cIFN production and bioactivity obtained were 168, 1.24 g/L and 5.4×10 U/mL, respectively.

关键词： bioactivity pastoris maximum induction optimized

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Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

《化学科学与工程前沿（英文）》 2021年第15卷第5期页码 1322-1331 doi: 10.1007/s11705-021-2036-z

摘要： For high performance supercapacitors, novel hierarchical yolk-shell -Ni(OH) /Mn O microspheres were controllably synthesized using a facile two-step method based on the solvothermal treatment. The unique -Ni(OH) based yolk-shell microstructures decorated with numerous interconnected nanosheets and the hetero-composition features can synergistically enhance reactive site exposure and electron conduction within the microspheres, facilitate charge transfer between electrolyte and electrode materials, and release structural stress during OH chemisorption/desorption. Moreover, the Mn O sediments distributed over the -Ni(OH) microspheres can serve as an effective protective layer for electrochemical reactions. Consequently, when tested in 1 mol·L KOH aqueous electrolyte for supercapacitors, the yolk-shell -Ni(OH) /Mn O microspheres exhibited a considerably high specific capacitance of 2228.6 F·g at 1 A·g and an impressive capacitance retention of 77.7% after 3000 cycles at 10 A·g . The proposed -Ni(OH) /Mn O microspheres with hetero-composition and unique hierarchical yolk-shell microstructures are highly promising to be used as electrode materials in supercapacitors and other energy storage devices.

关键词：

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

《结构与土木工程前沿（英文）》 2018年第12卷第3期页码 341-351 doi: 10.1007/s11709-017-0393-y

摘要：

Slippage corresponds to the relative displacement of a bolted joint subjected to shear loads since the construction clearance between the bolt shank and the bolthole at assembly can cause joint slip. Deflections of towers with joint slippage effects is up to 1.9 times greater than the displacements obtained by linear analytical methods. In this study, 8 different types of joints are modelled and studied in the finite element program, and the results are verified by the experimental results which have been done in the laboratory. Moreover, several types of joints have been modelled and studied and load-deformation curves have also been presented. Finally, joint slip data for different types of angles, bolt diameter and bolt arrangements are generated. Thereupon, damping ratios (z) for different types of connections are reported. The study can be useful to help in designing of wind turbine towers with a higher level of accuracy and safety.

关键词： Joint slip cyclic loading Finite element modelling Experimental joint behavior damping ratios (

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Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年第13卷第2期页码 238-249 doi: 10.1007/s11684-017-0599-3

摘要： The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

关键词： interferon-α hematopoietic stem cell transplantation minimal residual disease donor lymphocyte infusion

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Testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional study

null

《医学前沿（英文）》 2017年第11卷第4期页码 528-535 doi: 10.1007/s11684-017-0573-0

摘要：

The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette–Guérin (BCG) booster vaccination in China was estimated using tuberculin skin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccination on the performance of TST. Data analysis was conducted for 2831 eligible participants aged 5–15 years from the baseline survey of a population-based multi-center prospective study. The prevalence rates of TST (induration≥10 mm) and QFT positivity were 9.3% (264/2827) and 2.5% (71/2831), respectively. The rate of QFT indeterminate result was 2.2% (62/2831). The overall agreement between TST and QFT was low (concordance= 88.0%; κ coefficient= 0.125). Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidence interval, 1.26–2.31]. A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT. Our results suggested that BCG neonatal vaccination still affects TST performance, and a two-step approach might be considered for TB infection testing among adolescents in China.

关键词： tuberculin skin test interferon-γ release assays adolescent agreement

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Anti-β₂GPI/β₂GPI complexes induce platelet activation and promote thrombosis via p38MAPK: a pathway to targeted therapies

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

《医学前沿（英文）》 2019年第13卷第6期页码 680-689 doi: 10.1007/s11684-018-0673-5

摘要： Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosis. Anti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells via the intracellular NF- B pathway with prothrombotic implications. By contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studied. The p38 mitogen-activated protein kinase (MAPK) pathway has been recognized to be an important intracellular signaling pathway in the coagulation cascade and an integral component of arterial and venous thrombosis. The present study reveals that levels of anti- GPI/ GPI complexes in sera are positively associated with p38MAPK phosphorylation of platelets in thrombotic patients. Furthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation. Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes. In conclusion, p38MAPK may be a treatment target for anti- GPI antibody-associated thrombotic events.

关键词： anti-

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Phase separation in cGAS-STING signaling

《医学前沿（英文）》页码 855-866 doi: 10.1007/s11684-023-1026-6

摘要： Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

关键词： biomolecular condensates phase separation cGAS-STING pathway cGAS STING cGAMP interferon

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Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

《机械工程前沿（英文）》 2007年第2卷第2期页码 235-238 doi: 10.1007/s11465-007-0041-7

摘要： This paper analyzed the inverse kinematics for the new Parallel rotate slider- axes (PRS-) style hybrid machining tool and educed the five axes linkage inverse kinematics transform formula on the basis of the coordinates of the and virtual axes. The program for the PRS-XY style hybrid machining tool in accordance with the program manner for the common numerical control (NC) machine tool was made. The results of the experiments prove that the inverse kinematics transform formula is correct.

关键词： numerical accordance transform formula virtual slider-

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海上风机桩式基础结构形式综合模糊优选

翟钢军,李玉刚,康海贵

《中国工程科学》 2010年第12卷第11期页码 40-46

摘要：

style="text-align: justify;">针对海上风机基础设计中经常遇到复杂的方案优化选型问题，将多因素、多级模糊优选理论引入到基础的设计选型中。

关键词：海上风机桩基选型优化模糊决策

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

《医学前沿（英文）》 2023年第17卷第3期页码 549-561 doi: 10.1007/s11684-022-0965-7

摘要： Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

关键词： pregnancy IgG glycome type I interferon systemic lupus erythematosus

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Dynamic performance of submerged floating tunnel with different mooring styles subjected to anchor cable failure

《结构与土木工程前沿（英文）》 doi: 10.1007/s11709-023-0932-7

摘要： Submerged floating tunnels (SFTs) are novel structures for transportation across long- and deep-strait regions. Owing to severe wave and current excitation as well as the effects of underwater structures and corrosion, the risk of local anchor cable failure is high, which can result in the progressive failure of the entire structure. In this study, experimental and numerical investigations are conducted to analyze the dynamic behavior of an SFT with different mooring styles under local cable failure. A custom-designed cable failure device and the birth-and-death element method are used to simulate cable failure (i.e., progressive failure) via experiments and numerical simulation, respectively. A physical-scale segmental model of an SFT with different mooring styles under anchor cable failure is developed in this study. A segmental and entire-length mathematical model is developed using the ANSYS program to perform the numerical simulation. The results of the segmental numerical and experimental models indicate good agreement. The dynamic response of an SFT with different mooring styles under cable failure is comprehensively investigated by investigating the effects of key parameters (wave period, buoyant weight ratio, and cable failure mechanism). Moreover, the progressive failure of the SFT under cable failure is investigated via a segment model test and a numerical simulation of its entire length. The present study can serve as a reference for the safer designs of the SFT mooring style.

关键词： dynamic behaviors submerged floating tunnel cable failure mooring style progressive failure

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三塔悬索桥人字型钢中塔选型及关键构造设计

华新,韩大章,周彦锋,徐瑞丰

《中国工程科学》 2010年第12卷第4期页码 37-42

摘要：

style="text-align: justify;">三塔悬索桥整体刚度低，中塔选择对整个结构的受力有非常显著的影响。

关键词：三塔悬索桥钢中塔选型关键构造设计

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深部裂缝带——一种新的地震构造样式

李愿军

《中国工程科学》 2006年第8卷第4期页码 12-18

摘要：

黄河黑山峡大柳树坝址、雅砻江锦屏普斯罗坝址及其他一些水电工程区，在勘探过程相继发现了一种新的地质构造现象——深部裂缝带，并且多出现在我国强震活跃地区和强震发生断裂带上，沿断裂带历史上强震活动频繁；深部裂缝带向地下延伸超过300m，远远超出地表卸荷带的影响深度，故与强地震作用时岩体构造动力效应密切相关；讨论了根据弹性波作用下岩体的动力学响应，阐述了深部裂缝带发生的地震学原因。

关键词：深部裂缝带强震断层卸荷岩石动力学

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钱学森——科技界的一面旗帜

涂元季

《中国工程科学》 2002年第4卷第2期页码 1-7

摘要：

文章回顾了钱学森的生平，介绍了他得益于良好的家庭教育和学校教育所形成的优秀品格，展示了钱学森在美国师从冯·卡门以后的出众才华和取得的丰硕成就；文章以鲜为人知的大量事实描述了钱学森为争取返回祖国而进行的不屈不挠的斗争，以及他回到祖国后为了我国的航天事业呕心沥血的事迹，并以具体事例向人们揭示了钱学森对待金钱、荣誉和地位的崇高思想境界与高尚品德。

关键词：生平求知科技攻关工作作风思想品德革命情操

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标题作者时间类型操作

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

期刊论文

Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

期刊论文

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

期刊论文

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

Testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional study

null

期刊论文

Anti-β₂GPI/β₂GPI complexes induce platelet activation and promote thrombosis via p38MAPK: a pathway to targeted therapies

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

期刊论文

Phase separation in cGAS-STING signaling

期刊论文

Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

期刊论文

海上风机桩式基础结构形式综合模糊优选

翟钢军,李玉刚,康海贵